Xeomin is a prescription medicine that is injected into muscles and used to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults.
When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.
Botulinum toxin type A – the active ingredient in Xeomin acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, Xeomin can temporarily reduce the lines between your eye-brows.
Xeomin was proven effective in two randomized, double blind, multicenter, placebo controlled clinical trials of 547 healthy adult patients. The average age of patients in the study was 46 years. Patients received 20 units of Xeomin and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment was higher with Xeomin than with Placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, Xeomin received federal approval for use in glabellar lines in 2011.
You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.